RecruitingPhase 2NCT06319027

Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial

Phase II Glioblastoma Accelerated Biomarkers Learning Environment Trial (GABLE)


Sponsor

ECOG-ACRIN Cancer Research Group

Enrollment

100 participants

Start Date

Apr 11, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This phase II trial studies whether different imaging techniques can provide additional and more accurate information than the usual approach for assessing the activity of tumors in patients with newly diagnosed glioblastoma. The usual approach for this currently is magnetic resonance imaging (MRI). This study is trying to learn more about the meaning of changes in MRI scans after treatment, as while the appearance of some of these changes may reflect progressing tumor, some may be due the treatment. Dynamic susceptibility contrast (DSC)-MRIs, along with positron emission tomography (PET) and/or magnetic resonance (MR) spectroscopy, may help doctors tell which changes are a reflection of the treatment and which changes may be due to progressing tumor.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study — called the GABLE Trial — collects MRI brain scan data from patients with newly diagnosed glioblastoma (a highly aggressive brain cancer) to develop better tools using imaging to predict how the cancer will progress. The goal is to improve future treatment planning using AI-driven image analysis. **You may be eligible if...** - You are 18 years or older - You have been newly diagnosed with glioblastoma (IDH wild-type, confirmed by the 2021 WHO criteria) - You are planning to receive standard-of-care treatment for glioblastoma - You have had an MRI scan before your diagnostic surgery and a post-operative MRI within 3 weeks after surgery - Your performance status is adequate (Karnofsky score 60% or higher) **You may NOT be eligible if...** - Your glioblastoma was not newly diagnosed (e.g., recurrent) - You did not have the required MRI scans done - Your performance status is too low Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREDynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging

Undergo DSC-MRI

OTHERFluciclovine F18

Given IV

DRUGGadolinium-Chelate

Receive gadolinium-based contrast agent

PROCEDUREMagnetic Resonance Spectroscopy

Undergo MR spectroscopy

PROCEDUREPositron Emission Tomography

Undergo PET scan


Locations(1)

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, United States

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NCT06319027


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