Renin-guided Hemodynamic Management in Patients With Shock
Effect of Personalized Hemodynamic Management Based on Serum Renin Concentration on Acute Kidney Injury Progression in Patients With Shock: a Randomized Controlled Trial.
Università Vita-Salute San Raffaele
800 participants
Jan 27, 2025
INTERVENTIONAL
Conditions
Summary
Shock is a major risk factor for mortality among patients admitted to intensive care units (ICUs). Since various hemodynamic strategies uniformly delivered to patients with shock have failed to improve clinically relevant outcomes, individualized approaches for shock supported by robust evidence are required. This study will be a prospective, multicenter, parallel-group, single-blind, randomized controlled trial. The investigators will randomly assign 800 critically ill patients requiring norepinephrine infusion to the renin-guided or usual care groups. The investigators hypothesize that renin-guided hemodynamic management, compared to usual care, can reduce a composite of mortality and acute kidney injury (AKI) progression in patients requiring vasopressor support.
Eligibility
Plain Language Summary
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Interventions
If normalization of renin levels is achieved (values within the normal laboratory range), we will continue with usual care according to local protocols.
Standard of care
Locations(3)
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NCT05898126