Perioperative Treatment With Tranexamic Acid in Melanoma

This study is testing tranexamic acid — a medication that reduces bleeding — given around the time of surgery to see if it can lower the risk of melanoma spreading. Some research suggests that limiting blood loss during surgery may reduce cancer spread. **You may be eligible if...** - You have been diagnosed with invasive melanoma (thicker than 1mm with ulceration, or thicker than 2mm) - You are eligible for surgery (wide local excision and sentinel lymph node biopsy) - You are between 18 and 80 years old **You may NOT be eligible if...** - You have had a prior invasive melanoma - You had a blood clot (deep vein thrombosis or pulmonary embolism) in the last 3 months - You are pregnant or breastfeeding - You have a known allergy to tranexamic acid - You have epilepsy or a history of seizures - Your kidney function is significantly impaired (eGFR 0–50) - You are already using tranexamic acid Talk to your doctor to see if this trial is right for you.