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RecruitingPhase 2NCT05909150

Hypertonic Saline Solution to Prevent Acute Kidney Injury After Heart Transplantation

Use of Hypertonic Saline Solution to Prevent Acute Kidney Injury After Heart Transplantation

Sponsor

Fernando Bacal

Enrollment

74 participants

Start Date

Nov 8, 2023

Study Type

INTERVENTIONAL

Conditions

Acute Kidney InjuryHeart Transplantation

Summary

The goal of this study is to evaluate if hypertonic saline solution can prevent or attenuate acute kidney injury after heart transplantation in the early postoperative phase.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Hospitalized patients submitted to orthotopic heart transplantation (HT)

Exclusion Criteria6

  • Requirement of renal replacement therapy at the time of HT
  • Requirement of extracorporeal membrane oxygenation (ECMO) before or immediately after HT
  • Severe peri-operative mechanical complications
  • Double transplant (e.g. heart-kidney or heart-lung)
  • Hypernatremia (Na ≥ 145)
  • Severe hyponatremia (Na ≤ 120)

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Interventions

DRUGSodium chloride solution 3,5%

Patients will receive 150 mL HSS 3,5% intravenous twice daily for 3 days after heart transplantation.

DRUGSodium chloride solution 0,9%

Patients will receive 150 mL NS 0,9% intravenous twice daily for 3 days after heart transplantation.

Locations(1)

Heart Institute, University of São Paulo.

São Paulo, Brazil

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NCT05909150

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