RecruitingNot ApplicableNCT05916417

TMS-fNIRS Personalized Dosing

Sponsor

Florida State University

Enrollment

60 participants

Start Date

Jan 19, 2024

Study Type

INTERVENTIONAL

Conditions

Traumatic Brain Injury Post Traumatic Stress Disorder

Summary

The intent of this study is to establish technical feasibility in a clinical population (PTSD, with or without mild TBI) of personalized TMS-fNIRS technology. Thereby demonstrating the utility of transcranial magnetic stimulation - functional near-infrared spectroscopy (TMS-fNIRS) technology as a direct measure of frontal brain activity, potentially replacing the indirect motor threshold procedure that may lead to improper dosing of TMS. Personalized TMS-fNIRS technology will guide therapy for depression, post-traumatic stress disorder (PTSD), and/or traumatic brain injury (TBI)

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is personalizing the dose of TMS (transcranial magnetic stimulation — a non-invasive brain stimulation treatment) for PTSD by using a brain imaging technique (fNIRS) to measure individual brain responses in real time. **You may be eligible if...** - You are 18–70 years old - You have a confirmed diagnosis of PTSD - You are being considered for TMS treatment for PTSD - Your psychiatric medications and therapy have been stable for at least 1 month **You may NOT be eligible if...** - You have metal implants in your head or a pacemaker - You have a history of seizures - You are pregnant - You have a current severe psychiatric crisis requiring immediate hospitalization - Your medication regimen has changed recently Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETMS-fNIRS over the dl-PFC

Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technology. Functional Near Infrared Spectroscopy (fNIRS) is a brain imaging technology that utilizes light.