Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus

This observational study is collecting and analyzing tissue samples and blood markers from patients with throat cancer (oropharyngeal cancer) or hidden tumors in neck lymph nodes that are linked to the human papillomavirus (HPV). The researchers are studying specific biological markers — including microRNAs and viral signals — to better understand how these cancers behave and respond to treatment. **You may be eligible if:** - You are over 18 years old - You have been diagnosed with squamous cell carcinoma of the oropharynx (back of the throat, tonsils, or base of tongue) or a hidden primary tumor with HPV-positive lymph node involvement - You are scheduled to be treated with surgery, radiation, or chemoradiation - You are well enough to follow study procedures and complete questionnaires **You may NOT be eligible if:** - Your cancer has already spread to distant parts of the body (distant metastases) at the time of diagnosis - You have previously had a head or neck cancer - You have or have had a second cancer that is currently being treated or has been in follow-up for less than 5 years Talk to your doctor to see if this trial is right for you.