Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy

This study is investigating whether a nerve-stimulation treatment called low-level vagus nerve stimulation (or a similar non-invasive technique) can protect the heart from damage caused by anthracycline chemotherapy — a class of powerful chemotherapy drugs used for breast cancer and lymphoma that can cause heart problems over time. The treatment aims to activate the body's own nervous system to reduce inflammation and heart stress during chemotherapy. **You may be eligible if:** - You are over 18 years old - You have received anthracycline-based chemotherapy for breast cancer or lymphoma within the past 30 days - You have at least one additional heart disease risk factor, such as: age over 50, type 2 diabetes, high blood pressure, current smoking, obesity, previous heart attack, established heart disease or significant valve disease, or chronic kidney disease - You also had previous chest radiation **You may NOT be eligible if:** - You have a paced heart rhythm (an artificial pacemaker controlling your heart rate) - You have a history of seizures that are currently being treated - You have a history of fainting episodes (vasovagal syncope) - You have end-stage liver or kidney disease Talk to your doctor to see if this trial is right for you.