Modulation of Brain Oscillations Underlying Working Memory
State-dependent Modulation of Interactions of Theta and Gamma Rhythms in Working Memory
Massachusetts General Hospital
32 participants
Jul 10, 2024
INTERVENTIONAL
Conditions
Summary
This study will use novel transcranial alternating current stimulation (tACS) protocols and electroencephalography (EEG) to modulate and measure brain oscillations that underlie working memory. tACS is a noninvasive method used to modulate the timing and patterns of brain rhythms via weak electric currents passed through electrodes on the scalp.
Eligibility
Inclusion Criteria2
- Able to provide informed consent
- Fluent in English.
Exclusion Criteria4
- History of a neurological/psychiatric disorder
- Current use of psychotropic medications
- Current use of substances and drugs that were shown to affect tES (transcranial electrical stimulation) efficacy (dopamine altering drugs, nicotine, NMDA (N-methyl-D-aspartate) antagonists/agonists, sodium/calcium channel blockers, norepinephrine reuptake inhibitors, GABAergic modulators and selective serotonin reuptake inhibitors)
- Contraindications for tACS (e.g., history of seizures, metallic implants in the head or neck, implanted brain stimulators, vagus nerve stimulators, pacemakers, pregnancy)
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Interventions
Active tACS will be administered over the left dorsolateral prefrontal cortex for approximately 25 minutes.
Placebo tACS will be administered over the left dorsolateral prefrontal cortex for approximately 25 minutes.
Locations(1)
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NCT05923606