RecruitingNot ApplicableNCT07319117

Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.

A Double-blind, Placebo-controlled, Randomised, Acute, Repeated Measures Cross-over Study to Evaluate the Impact of Skoshify 'Think Tank' Nutritional Formulation on Cognitive Performance Following Stress Exposure.


Sponsor

Leeds Beckett University

Enrollment

40 participants

Start Date

Dec 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor. Adopting a double-blind repeated measures cross-over design, middle-aged females (40-60 years) will be recruited to take part in a two-stage research study that will examine whether the formulation enhances cognitive performance and subjective well-being following the challenge of a stressor, compared to placebo. Cognitive assessments will examine the impact of the nutritional formulation on working memory, sustained attention, cognitive flexibility and inhibitory control. The study will also assess physiological (heart rate, blood pressure and cortisol) and subjective (well-being, anxiety, positive and negative mood, stress) markers of stress reactivity. The study will also explore levels sleep quality, mental and physical fatigue, effort, productivity, and perceived impact of the intervention.


Eligibility

Sex: FEMALEMin Age: 40 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a nutritional supplement to see whether it can help healthy middle-aged women maintain cognitive performance (memory, focus, thinking) during stressful situations, compared to a regular caffeinated drink. **You may be eligible if...** - You are a woman between 40 and 60 years old - You drink caffeine daily - You are healthy, with no significant physical or psychiatric conditions - You drink coffee and are willing to consume the study products **You may NOT be eligible if...** - You currently smoke or vape - You have a food allergy or intolerance to the study products - You have been diagnosed with a psychiatric or cardiovascular condition - You take prescription medications (except contraceptives or hormone replacement therapy) - You have Raynaud's disease or circulation problems - You have had a hand/arm injury or infection in the past month, or have chronic pain or extreme cold sensitivity - You have had a brain injury or surgery - You work night shifts - You are pregnant or breastfeeding - You have previously taken part in a laboratory stress study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTSkoshify 'Think Tank' Formulation

Each acute dose contains, Magnesium 105mg, Sodium 5mg, Creatine Monohydrate 2.5g, Magnesium Gluconate 2g, L-Tyrosine 500mg, Phosphatidylserine 20% powder 200mg, L-Theanine 200mg, Citicoline Sodium 125mg, Rhodiola Rosea Root Extract 100mg.

OTHERPlacebo

The placebo contains Maltodextrin from corn 1.5mg and Organic acacia gum powder 0.5g.


Locations(1)

Leeds Beckett University

Leeds, West Yorkshire, United Kingdom

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NCT07319117


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