ClinicalTrialsFinder
RecruitingNot ApplicableNCT05933707

Small Extracellular Vesicles and Insulin Action

Effect of Small Extracellular Vesicles From Adipose Tissue on Insulin Action

Sponsor

Washington University School of Medicine

Enrollment

72 participants

Start Date

Jun 8, 2023

Study Type

INTERVENTIONAL

Conditions

ObesityInsulin ResistanceMetabolically Healthy ObesityObesity, Metabolically Benign

Summary

The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop obesity-related conditions; 2) assess the effect of small extracellular vesicles (sEVs also called exosomes), obtained from human participants, on metabolic function in cultured cells and in mice.

Eligibility

Min Age: 25 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called People with Metabolically Unhealthy Obesity - Low Calorie Diet for people with insulin resistance, metabolically healthy obesity, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 25 Years to 55 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BEHAVIORALPeople with Metabolically Unhealthy Obesity - Low Calorie Diet

Consumption of a low-calorie diet with caloric intake reduced by \~25% to achieve \~10% weight loss in about 4 to 5 months.

Locations(1)

Washington University School of Medicine

St Louis, Missouri, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05933707

Related Trials

Evaluation of the Care Pathway Offered by the "Chronic Disease Unit" to Obese Patients

NCT065382201 location

A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body

NCT074073481 location

A Study of LY3971297 in Healthy Participants

NCT061482727 locations

Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)

NCT072258161 location

Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity

NCT0749788023 locations