RecruitingNot ApplicableNCT05934747

Aim 3 Particle Swarm Optimization PIGD

Aim 3 Particle Swarm Optimization Postural Instability Gait Disorder

Sponsor

University of Minnesota

Enrollment

30 participants

Start Date

Mar 19, 2024

Study Type

INTERVENTIONAL

Conditions

Parkinson's Disease and Parkinsonism

Summary

In Parkinson's disease (PD) patients undergoing standard-of-care Deep Brain Stimulation (DBS) therapy, to compare the effect on Parkinson's symptoms of two different neurostimulator settings designed to differ from each other as much as possible with respect to how much they activate two different neuroanatomical structures: the axonal pathway from Globus Pallidus (GP) to Pedunculopontine Nucleus (PPN), and the axonal pathway from PPN to GP.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a technique called "particle swarm optimization" to fine-tune deep brain stimulation (DBS) settings in people with Parkinson's disease. DBS involves implanted electrodes in the brain that deliver electrical pulses to help control movement. The goal is to find the best stimulation settings to improve walking (gait). **You may be eligible if...** - You have Parkinson's disease - You have bilateral (both sides) deep brain stimulation implants in the STN or GP brain region - Your implant has been in place for at least 3 months - You are aged 18–85 - You have adequate cognitive ability to consent (MoCA score 23+ or confirmed by additional assessments) - You had a 7T MRI and post-operative CT scan as part of your care **You may NOT be eligible if...** - You cannot walk even with a safety harness in the off-medication, off-stimulation state - Your walking problems are primarily caused by something other than Parkinson's - There are technical issues with your DBS device (broken contacts, battery nearly dead) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.