RecruitingNot ApplicableNCT06508801

Blood Flow Restriction for Optimizing Balance in Parkinson's Disease


Sponsor

The University of Texas Health Science Center at San Antonio

Enrollment

20 participants

Start Date

Jan 7, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study is being done to understand how reducing blood flow (BRT) during balance-challenging strengthening exercises (instability resistance training, or IRT) can help improve symptoms of Parkinson's disease.


Eligibility

Min Age: 40 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a technique called blood flow restriction (BFR) training — where a cuff is used to mildly restrict blood flow to the limbs during exercise — can help improve balance in people with Parkinson's disease. The goal is to make exercise more effective even at lower intensities. **You may be eligible if...** - You are between 40 and 85 years old - You have been diagnosed with Parkinson's disease - Your Parkinson's is at a moderate stage (Hoehn and Yahr stage 2–4) - Your thinking and memory are adequate (mini-mental status score 23 or above) **You may NOT be eligible if...** - You have cardiovascular disease, uncontrolled high blood pressure, dizziness when standing, blood clots (deep-vein thrombosis), or varicose veins - You have poor circulation in your legs (low ankle-brachial index) - You have another neurological disorder affecting your balance or movement - You have significant joint or musculoskeletal problems that prevent exercise Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBlood flow restriction training

The BFR Intervention will consist of 75 repetitions; reps (set 1: 30 reps, sets 2 - 4: 15 reps with 30 s of rest between sets and 1 minute between exercises) at 20-30% of 10 repetition maximum (RM). BFR training will be performed during toe raises, lunges and single leg stance exercises on unstable surfaces (i.e., foam, Dyna disc, balance disc, and BOSU-ball®) as tolerated by the participant.

OTHERInstability Resistance Training

The following devices will be used for instability training: foam, dyna disc, balance disc and BOSU-ball®. Unstable devices will be changed during the six-week period from the least to the most unstable devices. Once a participant reduces the body sway on a device, the device will be progressed. Participants will perform IRT with or without blood flow restriction.


Locations(1)

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

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NCT06508801


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