RecruitingNot ApplicableNCT05962489

Sleep-specific DBS Therapy in Parkinson's Disease

Sponsor

University of Minnesota

Enrollment

64 participants

Start Date

Jun 22, 2023

Study Type

INTERVENTIONAL

Conditions

Dystonia Deep Brain Stimulation Parkinson's Disease and Parkinsonism

Summary

Sleep-wake disturbances are a major factor associated with reduced quality of life of individuals with Parkinson's disease (PD), a progressive neurological disorder affecting millions of people in the U.S and worldwide. The brain mechanisms underlying these sleep disorders, and the effects of therapeutic interventions such as deep brain stimulation on sleep-related neuronal activity and sleep behavior, are not well understood. Results from this study will provide a better understanding of the brain circuitry involved in disordered sleep in PD and inform the development of targeted therapeutic interventions to treat sleep disorders in people with neurodegenerative disease.

Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether adjusting deep brain stimulation (DBS) — a treatment that uses electrical pulses sent through implanted brain electrodes — during sleep can improve sleep quality and motor symptoms in people with Parkinson's disease. **You may be eligible if...** - You have been diagnosed with Parkinson's disease - You are at least 21 years old - You are planning to have or already have a DBS system implanted in your brain as part of your regular care - You are having your DBS surgery at the University of Minnesota **You may NOT be eligible if...** - You are not a candidate for or not planning DBS surgery - Your surgery is not being performed at the University of Minnesota - You have conditions that make 7T brain MRI unsafe (e.g., certain metal implants) - You are unable to participate in overnight sleep monitoring sessions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERClinically optimized deep brain stimulation

Participants will have DBS implanted as standard-of-care. We will be examining the effects of their regular clinical stimulation settings versus no stimulation.