RecruitingNCT05935605

Pulmonary Hypertension in Left Heart Disease

Comparison of Noninvasively-Obtained Echocardiographic Doppler Parameters With Simultaneously-Measured Invasive Hemodynamics in Patients Referred for Right Heart Catheterization

Sponsor

Mayo Clinic

Enrollment

3,000 participants

Start Date

Jul 20, 2023

Study Type

OBSERVATIONAL

Conditions

Pulmonary Hypertension Pulmonary Vascular Disease Left Heart Disease

Summary

The goal is to compare patients with and without varying severity of pulmonary vascular disease based upon hemodynamic signatures, echocardiographic measures, and lung ultrasound, in tandem with expired gas metabolic testing and blood sampling.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining pulmonary hypertension (high blood pressure in the lungs) that occurs in people with left heart disease — meaning the high lung pressure is caused by problems with the left side of the heart, including heart failure with preserved or reduced pumping function. Participants are already undergoing a heart catheter procedure for clinical reasons. **You may be eligible if...** - You are being referred for an invasive right heart catheterization (a standard cardiac procedure) for any reason - You have left heart disease, such as heart failure with preserved ejection fraction (HFpEF), heart failure with reduced ejection fraction (HFrEF), or significant valve disease - You have symptoms such as shortness of breath or fatigue **You may NOT be eligible if...** - You do not have a form of left heart disease - You are not already scheduled for a heart catheterization procedure - You do not meet other specific criteria determined by your cardiologist Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTTransthoracic Echocardiography (TTE)

Transthoracic echocardiography using ultrasound waves will be conducted during the rest and exercise phases of the clinically indicated invasive hemodynamic assessment by right heart catheterization to gather additional measurements of right ventricular function.

DIAGNOSTIC_TESTLung ultrasound

A lung ultrasound, which uses sound waves to produce images of the lungs, will be used to assess extravascular lung fluid during the rest and exercise phases of the clinically indicated invasive hemodynamic assessment by right heart catheterization.

Locations(1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

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NCT05935605

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