Impact of Bright Light Therapy on Prader-Willi Syndrome

This study tests whether bright light therapy — a treatment commonly used for sleep disorders and seasonal depression — can reduce excessive daytime sleepiness in people with Prader-Willi Syndrome (PWS), a rare genetic condition that commonly causes extreme fatigue, overeating, and behavioral challenges. The study uses a placebo-controlled design conducted entirely through remote visits over 8 weeks. Children and adolescents aged 6 to 18 with a genetic diagnosis of PWS and significant daytime sleepiness (as measured by a standard scale) may be eligible, while those with eye conditions sensitive to bright light, prior light therapy treatment, or active psychosis or mania are excluded. Participation involves using a light therapy device at home for several weeks and attending weekly virtual visits with the study team. This summary was generated with AI assistance to help patients understand the study in plain language.