RecruitingNot ApplicableNCT05947045

Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors

Sponsor

St. Jude Children's Research Hospital

Enrollment

45 participants

Start Date

Jun 22, 2023

Study Type

INTERVENTIONAL

Conditions

Brain Tumor

Summary

The objective of this study is to estimate the feasibility and acceptability of cognitive training in the virtual reality setting with children undergoing radiotherapy for brain tumors. To achieve this goal, the investigators plan to study children undergoing radiotherapy for brain tumors randomly assigned to cognitive training administered via an iPad or virtual reality. Both groups will also participate in cognitive testing and exams using functional near infrared spectroscopy (fNIRS) pre- and post-intervention. The questions to be investigated are: 1. Will cognitive training via virtual reality be feasible and acceptable for children undergoing radiotherapy for brain tumors as indicated by participation rates, adherence and frequency of side effects? 2. Will cognitive training via virtual reality provide neurocognitive benefits? 3. Will there be predictable changes in brain activity as measured by neuroimaging? Findings from this study will be used to develop a larger, definitive trial with direct potential to improve cognitive outcomes for children treated for cancer using a safe and effective alternative to desktop- or laptop-based computerized cognitive interventions with great promise for improving quality of life.

Eligibility

Min Age: 8 YearsMax Age: 22 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether computerized cognitive training (Cogmed) delivered in a virtual reality setting can help children and young adults who are undergoing brain tumor radiation therapy maintain or improve their thinking and memory skills. Radiation to the brain can affect cognition, and the researchers want to see if this program helps. **You may be eligible if...** - You are between 8 and 22 years old and are starting radiation therapy for a brain tumor - English or Spanish is your primary language - You and a parent are both willing to participate - You are willing to complete the required Cogmed training sessions **You may NOT be eligible if...** - Your IQ is below 70 (significant intellectual impairment) - You had a significant neurological condition before your brain tumor diagnosis (such as a stroke) - You have a major sensory or motor impairment that prevents using the virtual reality equipment Talk to your doctor to see if this trial is right for you.

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Interventions

OTHERCognitive training via iPad

Participants will complete five sessions of the Cogmed training program on an iPad. Participants will complete sessions over the course of one to two weeks while on campus for radiotherapy. Each session will take place in the Psychology Clinic and consist of 15 to 20 minutes of Cogmed training.

OTHERCognitive training via virtual reality

Participants will complete five sessions of the Cogmed training program within virtual reality. Participants will complete sessions over the course of one to two weeks while on campus for radiotherapy. Each session will take place in the Psychology Clinic and consist of 15 to 20 minutes of Cogmed training.

Locations(1)

St. Jude Children's Research Hospital

Memphis, Tennessee, United States

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NCT05947045

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