Dissecting the Cellular and Molecular Atlas of Rheumatoid Arthritis in Sustained Remission to Identify Pathways Maintaining Remission and Triggering Flares

This study is examining the cells and molecules in the joints of rheumatoid arthritis (RA) patients who are in sustained remission (no active disease) to understand what keeps the disease quiet — and what might trigger a flare. This knowledge could help develop strategies to maintain remission and prevent relapses. **You may be eligible if...** - You have been diagnosed with rheumatoid arthritis (based on 2010 EULAR/ACR criteria) - You have been in sustained remission for at least 6 months (DAS28-CRP score below 2.6) - You have been on stable medications (conventional or biologic DMARDs) for at least 12 months - You have not been on steroids for at least 6 months - Ultrasound of your joints shows no signs of active inflammation on three separate assessments **You may NOT be eligible if...** - Your disease activity score (DAS28-CRP) is 2.6 or higher - Ultrasound shows active blood flow signals in your joints - You have another chronic inflammatory disease Talk to your doctor to see if this trial is right for you.