RecruitingPhase 2NCT05959434

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and Co-Occurring PTSD: A Randomized Clinical Trial


Sponsor

Texas A&M University

Enrollment

200 participants

Start Date

Apr 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to test the efficacy of a novel integrative cognitive-behavioral intervention in patients with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Specific Aim 1: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing alcohol frequency (percent days drinking) and quantity (drinks per drinking day) as measured by the Timeline Follow-Back (TLFB). Specific Aim 2: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing PTSD symptoms as measured by the Clinician Administered PTSD Scale (CAPS-5). Specific Aim 3: Use ecological momentary assessment (EMA) to evaluate intervention effects on daily alcohol-related cognitions and behaviors through real-time associations with PTSD symptomatology and distress tolerance. Researchers will compare integrative CPT+RP with RP-alone to see if CPT+RP is more efficacious in reducing alcohol use and PTSD symptom severity.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an integrated therapy that combines Cognitive Processing Therapy (CPT, a trauma treatment) with Relapse Prevention (RP, an alcohol treatment) for people who have both PTSD (post-traumatic stress disorder) and alcohol use disorder. The two conditions often co-occur and are difficult to treat separately. **You may be eligible if...** - You are 18 to 70 years old and currently meet criteria for both moderate-to-severe alcohol use disorder and PTSD - You drink heavily on most days (4+ drinks per day for women, 5+ for men) or heavily throughout the week - You are able to understand English - Any psychiatric medications have been stable for at least 4 weeks **You may NOT be eligible if...** - You have a history of psychotic disorder or bipolar disorder, or are at imminent risk of harming yourself or others - You are currently in active alcohol withdrawal requiring medical management - You are already enrolled in another evidence-based treatment for alcohol use disorder or PTSD - You are pregnant or breastfeeding (women) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCognitive Processing Therapy + Relapse Prevention

Cognitive-Behavioral Therapy that integrates Cognitive Processing Therapy for PTSD with Relapse Prevention for alcohol use disorder

BEHAVIORALRelapse Prevention

Cognitive-Behavioral Therapy that targets alcohol use, specifically


Locations(2)

Medical University of South Carolina

Charleston, South Carolina, United States

Texas A&M University

College Station, Texas, United States

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NCT05959434


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