RecruitingPhase 2NCT05961410

Eltrombopag for Peripheral Blood Stem Cell Harvest

Eltrombopag Plus G-CSF for Human CD34+ Cell Mobilization in Patients With Lymphoma Undergoing Autologous Stem Cell Harvest


Sponsor

National Taiwan University Hospital

Enrollment

46 participants

Start Date

Aug 15, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to explore the activity of eltrombopag in lymphoma patients receiving autologous hematopoietic stem cell harvest. The main questions it aims to answer are: * Determine the efficacy of adding eltrombopag during autologous hematopoietic stem cell mobilization and harvest. * Determine the pharmacokinetics and pharmacodynamics of serum eltrombopag concentration, circulating CD34+ cells during autologous hematopoietic stem cell mobilization. Participants will receiving additional eltrombopag during stem cell harvest procedure. The amount of harvested stem cells will be compared with historical group to see if eltrombopag could increase the amount of harvested stem cells.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether eltrombopag — a drug that stimulates the body to produce more platelets (blood clotting cells) — can improve the collection of stem cells from the blood in people with lymphoma preparing for a stem cell transplant. Poor stem cell collection is a common obstacle, and this trial aims to increase the yield. **You may be eligible if...** - You are 18 or older with Hodgkin or non-Hodgkin lymphoma - Your lymphoma is in complete response, partial response, or stable disease after at least 2 cycles of treatment - You are planned for ESHAP chemotherapy with or without a monoclonal antibody (such as rituximab or brentuximab) for stem cell collection - You have East-Asian heritage **You may NOT be eligible if...** - You have a history of blood clots - You have very high baseline platelet counts or documented abnormalities in your bone marrow cells - You have significant liver damage or are currently on hepatitis C treatment with interferon - You are pregnant or breastfeeding - You have another active cancer besides lymphoma Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGEltrombopag olamine

Patients will receive eltrombopag 75 mg/day from ESHAP D6 until end of stem cell harvest.


Locations(1)

National Taiwan University Hospital

Taipei, Taiwan

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05961410


Related Trials