Thromboxane Function in Women With Endometriosis
The Role of Thomboxane A2 and it's Receptor in Vascular Regulation in Women With Endometriosis
Penn State University
96 participants
Jan 1, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are: * Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women? * Do women with endometriosis have greater platelet activity than healthy women? Participants will take aspirin and/or placebo and will: * perform hand grip exercise and cold pressor tests * undergo iontophoresis and blood draw Researchers will compare women with and without endometriosis to see if there is a difference in neurovascular regulation.
Eligibility
Inclusion Criteria3
- Born with a uterus
- -45 years old
- With and without endometriosis
Exclusion Criteria15
- Currently pregnant or breastfeeding
- Diagnosed cardiovascular disease
- BMI over 35
- Nicotine use (e.g., smoking, chewing tobacco, vaping, etc.)
- Currently using hormone replacement therapy (or have used within previous 6 months)
- Known skin allergies or current rash, skin disease, disorders of pigmentation
- Diabetes
- Renal disease, renal artery stenosis, renal impairment
- Liver disease
- Stage II Hypertension (blood pressure >140/>90 mmHg)
- Hypotension (blood pressure < 90/60 mmHg)
- Raynaud's syndrome
- Any current medications which could conceivably alter cardiovascular responses (e.g. antihypertension medication, diuretic, digoxin)
- Allergy or hypersensitivity to investigational agents
- Immunosuppressed/immunocompromised
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
650 mg aspirin (Acetylsalicylic acid)
placebo capsule
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05962034