RecruitingNot ApplicableNCT05965518

High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV

A Pilot Trial of High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Older Adults With HIV

Sponsor

University of Alabama at Birmingham

Enrollment

60 participants

Start Date

Feb 5, 2024

Study Type

INTERVENTIONAL

Conditions

Arterial Stiffness Cognitive Dysfunction HIV

Summary

This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whether 16 weeks of structured high-intensity interval training (HIIT) can overcome vascular and cognitive impairments (Aim 1) to a greater extent than continuous moderate exercise. Additionally, investigator will seek to identify barriers to engagement in exercise and the participants' perceptions of the study and exercise interventions (Aim 2). This study will enroll 60 participants in Birmingham, Alabama. Data collection will occur at each visit, with baseline data collected at the initial visit with a 3-month follow-up occurring following completion of the intervention.

Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a high-intensity exercise program can improve blood vessel health and thinking/memory abilities in older adults living with HIV who have cognitive impairment — a common problem in this group, partly due to long-term effects of the virus and some HIV medications. **You may be eligible if...** - You are 50 years or older and living with HIV - You have been on HIV antiretroviral therapy (ART) for at least 12 months - You lead a mostly sedentary lifestyle (less than 150 minutes of moderate exercise per week) - You have some level of cognitive impairment as measured by the study screening tool - You can speak, read, and write in English **You may NOT be eligible if...** - You have been diagnosed with mitochondrial disease - You are currently using substances that would interfere with the study - You have serious heart conditions that make high-intensity exercise unsafe - You are currently using older HIV drugs known to cause mitochondrial toxicity Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALHigh-Intensity Interval Training

Following a 5-minute warm-up at 50% VO2peak, high and moderate-intensity exercise bouts alternate, progressing to five bouts of 4-minute high-intensity exercise (90% VO2peak), alternating with four 3-minute bouts of moderate-intensity exercise (50% VO2peak) by week 8, followed by a 5 minute cool-down. The total exercise time is 42 minutes.

BEHAVIORALContinuous Moderate Exercise

Following a 4 minute warm-up at 50% VO2peak, the participant walks for up to 42 continuous minutes at 60% VO2peak, followed by a 4 minute cool-down. The total exercise time is 50 minutes.