Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes
University of Cincinnati
10 participants
Oct 10, 2019
INTERVENTIONAL
Conditions
Summary
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D). In a previous study, it was observed in people without diabetes that fasting can be detrimental to the hormonal and hepatic responses to insulin-induced hypoglycemia. In the experiments described herein, the impact fasting has on hypoglycemic counterregulation in people with T1D will be determined.
Eligibility
Inclusion Criteria4
- males and females of any race or ethnicity
- non-obese (BMI \< or = to 30)
- have a diagnosis of type 1 diabetes
- C-peptide negative
Exclusion Criteria9
- pregnant women
- cigarette smoking
- Taking inflammation-targeting steroids (e.g., prednisone).
- Taking medications targeting adrenergic signaling (e.g., beta-blockers, bronchodilators).
- Hematocrit less than 33%.
- Presence of HIV or hepatitis (due to their deleterious effects on the liver).
- The presence of cardiovascular or peripheral vascular disease.
- The presence of neuropathy, retinopathy or nephropathy.
- A detection of the presence of any other disease or condition by one of the study doctors, that would be expected to confound the responses to insulin-induced hypoglycemia or make participation in the study dangerous to the individual.
Interventions
Subjects remain fasted prior to insulin-induced hypoglycemia.
Subjects eat a normal breakfast and lunch prior to insulin-induced hypoglycemia.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05973799