Identifying and Treating Depression in the Orthopaedic Trauma Population
Wake Forest University Health Sciences
100 participants
Jun 25, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are: 1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed either an Selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI). 2. What are the outcomes of patients who screen positive for depressive symptoms and choose not to pursue treatment with medication?
Eligibility
Inclusion Criteria4
- Patients presenting to an Orthopaedic trauma clinic for the first time following operative extremity fracture or any pelvis fracture
- A score of greater than or equal to 5 on the Patient Health Questionnaire-9 (PHQ-9) at first post- operative visit
- Age 18 or older
- Speak English or Spanish
Exclusion Criteria4
- Currently taking medication to treat depression
- Contraindication/allergy to one of the study medications
- Bipolar disorder of psychotic disorder
- Endorse suicidal ideation
Interventions
Fluoxetine 20 mg once daily
Duloxetine 30 mg once daily
Referral to behavioral health and resources for addressing depressive symptoms
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05976347