RecruitingPhase 4NCT05976347

Identifying and Treating Depression in the Orthopaedic Trauma Population

Sponsor

Wake Forest University Health Sciences

Enrollment

100 participants

Start Date

Jun 25, 2025

Study Type

INTERVENTIONAL

Conditions

Depression

Summary

The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are: 1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed either an Selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI). 2. What are the outcomes of patients who screen positive for depressive symptoms and choose not to pursue treatment with medication?

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether identifying and treating depression in patients who have had orthopaedic fracture surgery improves outcomes. Patients who show signs of depression at their first post-surgery clinic visit are offered medication treatment as part of the study. **You may be eligible if...** - You are 18 or older - You had surgery for a bone fracture in an arm, leg, or pelvis - You scored 5 or higher on a standard depression screening questionnaire (PHQ-9) at your first post-surgery visit - You speak English or Spanish **You may NOT be eligible if...** - You are already taking medication for depression - You have an allergy to the study medications - You have bipolar disorder or a psychotic disorder - You are currently having thoughts of suicide Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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