RecruitingNot ApplicableNCT05977803

Contribution of the CEST Sequence in the Characterization of Radionecrosis of Brain Metastases of Pulmonary Origin


Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

60 participants

Start Date

Feb 15, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of the study is to determine whether the use of the CEST sequence would have diagnostic performance equivalent to the reference method of T2\* infusion with contrast injection in the diagnosis of radionecrosis of lung cancer brain metastases.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This imaging study is testing whether a specialised MRI technique called CEST (Chemical Exchange Saturation Transfer) can help doctors distinguish between true regrowth of brain metastases from lung cancer and tissue damage caused by radiation treatment (radionecrosis), which can look similar on standard scans. **You may be eligible if...** - You are over 18 years old - You have been diagnosed with primary lung cancer - You have brain metastases (cancer that has spread to the brain) that were treated with radiotherapy - Your brain imaging shows a lesion that appears to have grown on a recent MRI (suggesting either recurrence or radiation damage) - You are covered by French social security **You may NOT be eligible if...** - You have a contraindication to MRI (e.g., pacemaker, certain implants) - You have severe cognitive impairment that prevents informed consent - You are under guardianship or in custody Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONMRI with CEST sequence, IVIM and ASL sequence

Three sequences will be added as part of the protocol (for an additional duration of about 10 minutes) : * The CEST sequence * The ASL infusion sequence * The IVIM sequence


Locations(1)

Hôpital Bichat-Claude Bernard

Paris, France

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NCT05977803


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