RecruitingNCT05984979

The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and Diabetes

The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and With Type 1 and 2 Diabetes: an Exploratory Study

Sponsor

University of Bern

Enrollment

60 participants

Start Date

Aug 7, 2023

Study Type

OBSERVATIONAL

Conditions

Diabetes Mellitus

Summary

Exhaled volatile organic compounds will be measured during daytime with the goal to identifying circadian variability. The study incudes three subgroups: people without diabetes, people with type 1 diabetes, and people with type 2 diabetes. A total of 60 people will be recruited for the study.

Eligibility

Min Age: 18 Years

Inclusion Criteria12

Subgroup 1:
Age 18 or older
HbA1c below 6.5%
Written informed consent
Subgroup 2:
Age 18 or older
T1D (Type 1 diabetes) with MDI (multiple daily injection) or CSII (Continuous subcutaneous insulin infusion therapy) therapy \>1 year
Written informed consent
Subgroup 3
Age 18 or older
T2D (Type 2 diabetes) with oral antidiabetic medication or insulin therapy
Written informed consent

Exclusion Criteria9

Pregnancy or breastfeeding
Smoking (last cigarette less than 6 months ago)
Any chronical lung and intestinal disease diagnosis (such as intestinal bowel disease (IBD); asthma; COPD (chronic obstructive pulmonary disease); lung cancer, …)
Coeliac disease
Lactose and fructose intolerance
Any acute disease diagnosis (such as viral or bacterial infection)
Drinking habit of more than four units of alcohol per day
Current inhaled medicines treatments
Antibiotic treatment in the previous 4 months