RecruitingNot ApplicableNCT05993390

Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients

Effect of Neuromuscular Reversal Agents on Time for Neurological Assessment After Endotracheal Intubation in Critically Ill Patients


Sponsor

Seoul National University Hospital

Enrollment

30 participants

Start Date

Jan 11, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to compare the effect of use of reversal agents for neuromuscular blockade in critically ill patients on time for neurological assessment after endotracheal intubation The main questions it aims to answer are: * The use of reversal agents for neuromuscular blockade after endotracheal intubation may reduce the time for neurological assessment. * The types of reversal agents for neuromuscular blockade may affect the time for neurological assessment. Participants will receive different reversal agents or no medications based on the assigned groups. Thirty minutes after intubation using rocuronium, medication is administered, and the time of initial confirmation of eye opening and movement is recorded. Researchers will compare 3 groups (sugammadex, neostigmine and control(no medication) to see the difference of time for neurological assessment after endotracheal intubation.


Eligibility

Min Age: 19 YearsMax Age: 90 Years

Inclusion Criteria1

  • Adult patients 19 years of age or older who were intubated after admission to the intensive care unit.

Exclusion Criteria5

  • Patients younger than 19 years of age
  • Patients who are not neurologically evaluable or have concomitant neurologic dysfunction
  • Patients with neuromuscular disorder
  • Patients with a history of drug allergic reactions to sugammadex or neostigmine
  • Patients taking or planning to take toremifene, fusidic acid, or hormonal contraceptives

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Interventions

DRUGSugammadex

Intravenous administration of sugammadex 2mg/kg.

DRUGNeostigmine

Intravenous administration of neostigmine 0.05mg/kg with glycopyrrolate 0.01mg/kg


Locations(1)

Seoul National University Hospital

Seoul, Jongno-gu, South Korea

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NCT05993390


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