CEST in Low-grade Glioma Study
A Multi-institutional Observational Study of CEST Imaging in Low-grade Glioma
Sunnybrook Health Sciences Centre
100 participants
Aug 12, 2022
INTERVENTIONAL
Conditions
Summary
Low grade gliomas (LGGs) are malignant, infiltrative and incurable brain tumours that typically present in the younger population. This project proposes to use non-contrast metabolic "Saturation Transfer" (ST)-MRI to evaluate LGG tumour progression and aims to predict early changes in LGG. Early identification of LGG patients whose tumours will progress will permit early interventions. ST-MRI does not involve any intravenous injection of contrast and which acquires metabolic information not seen by standard MRI.
Eligibility
Inclusion Criteria9
- Be at least 12 years of age;
- Diagnosed with:
- Cohort A (pre-surgical): Suspected LGG (oligodendroglioma or astrocytoma), based on any combination of histological, molecular, radiological, and/or clinical findings; or
- Cohort B (post-surgical): IDH1/2-mutant or IDH-wildtype (WT) low-grade glioma candidate for observation
- No contraindications to MRI;
- eGFR > 30 ml/min;
- No prior chemotherapy or radiation therapy;
- No need for upfront treatment (surgery, chemotherapy, and/or radiation therapy)
- Followed at either Sunnybrook Health Sciences Centre or at St Michael's Hospital
Exclusion Criteria2
- Need for upfront post-surgical treatment with either chemotherapy and/or radiation therapy
- Pregnancy
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Interventions
Non-contrast magnetic resonance imaging "Saturation Transfer" scans consisting of magnetization transfer (MT) and chemical exchange saturation transfer (CEST)
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT05996653