Low-grade Glioma Clinical Trials

16 recruiting

Low-grade Glioma Trials at a Glance

18 actively recruiting trials for low-grade glioma are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Phase 2 with 6 trials, with the heaviest enrollment activity in San Francisco, St Louis, and Boston. Lead sponsors running low-grade glioma studies include University of California, San Francisco, Day One Biopharmaceuticals, Inc., and Daniel Morgenstern.

Browse low-grade glioma trials by phase

Treatments under study

About Low-grade Glioma Clinical Trials

Looking for clinical trials for Low-grade Glioma? There are currently 16 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Low-grade Glioma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Low-grade Glioma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 118 of 18 trials

Recruiting
Phase 2

Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas

BRAF V600 MutationLow-grade GliomaLow Grade Glioma of Brain+1 more
University of California, San Francisco96 enrolled5 locationsNCT07110246
Recruiting
Early Phase 1

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

GliomaGlioma, MalignantLow-grade Glioma+2 more
Children's Hospital of Philadelphia30 enrolled1 locationNCT05555550
Recruiting
Not Applicable

Efficacy of Laser Interstitial Thermal Therapy in Young Persons With Low-grade Glioma

Pediatric CancerLow-grade GliomaLow Grade Glioma of Brain+1 more
University of California, San Francisco40 enrolled1 locationNCT07506239
Recruiting
Phase 1

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

High Grade GliomaLow-grade GliomaRecurrent World Health Organization (WHO) Grade II Glioma
University of California, San Francisco50 enrolled17 locationsNCT04485559
Recruiting
Phase 3

DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

Low-grade GliomaRapidly Accelerated Fibrosarcoma (RAF) Altered GliomaPediatric Low-grade Glioma
Day One Biopharmaceuticals, Inc.400 enrolled138 locationsNCT05566795
Recruiting
Phase 1

A Study of Avutometinib for People With Solid Tumor Cancers

Solid TumorSolid Tumor, AdultNeuroblastoma+12 more
Memorial Sloan Kettering Cancer Center23 enrolled2 locationsNCT06104488
Recruiting
Phase 1Phase 2

Phase 1/2 Study of Mirdametinib + Vinblastine for Newly Diagnosed/Previously Untreated PLGG + Activation of MAPK

Pediatric Low-grade Glioma
St. Justine's Hospital50 enrolled5 locationsNCT06666348
Recruiting

A Living Tissue Bank of Patient-Derived Organoids From Glioma Tumors

High Grade GliomaLow-grade Glioma
Maastricht Radiation Oncology50 enrolled1 locationNCT04865315
Recruiting
Not Applicable

Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

Low-grade Glioma
University of California, San Francisco97 enrolled1 locationNCT03948490
Recruiting
Not Applicable

Developing Fast Pediatric Imaging

Pediatric Low-grade Gliomas
Boston Children's Hospital300 enrolled3 locationsNCT03761121
Recruiting
Not Applicable

HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

Brain NeoplasmsBrain TumorCognitive Dysfunction+9 more
Dartmouth-Hitchcock Medical Center125 enrolled1 locationNCT06930846
Recruiting
Early Phase 1

Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas

Low-grade Glioma
Daniel Morgenstern57 enrolled1 locationNCT06381570
Recruiting
Phase 2

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

Advanced Solid TumorLow-grade Glioma
Day One Biopharmaceuticals, Inc.141 enrolled35 locationsNCT04775485
Recruiting
Phase 2

FG001 in Subjects with Meningiomas or Presumed Low-Grade Gliomas Scheduled for Neurosurgery

MeningiomaGliomaLow-grade Glioma
Rigshospitalet, Denmark40 enrolled1 locationNCT06684795
Recruiting

Monitoring of Patients With Low-grade Gliomas Using Circulating miRNA

GliomaBiomarkersLow-grade Glioma+1 more
University Hospital, Caen20 enrolled1 locationNCT06610851
Recruiting
Phase 2

Binimetinib in Patients With BRAF Fusion-positive Low-grade Glioma or Pancreatic Cancer (Perfume)

Pancreatic CancerLow-grade Glioma
National Cancer Center, Japan32 enrolled6 locationsNCT06159478
Recruiting
Not Applicable

CEST in Low-grade Glioma Study

Low-grade Glioma
Sunnybrook Health Sciences Centre100 enrolled2 locationsNCT05996653
Recruiting
Phase 2Phase 3

Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery

Low-grade Glioma
West China Hospital250 enrolled1 locationNCT04316039