RecruitingNot ApplicableNCT05996900

Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans


Sponsor

Stanford University

Enrollment

49 participants

Start Date

Sep 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key markers of the brain's response to repeated doses of TMS with high resolution using invasive brain recordings in humans, and relate these brain markers to noninvasive recordings. These markers will improve the understanding of TMS and can be used to optimize and enhance clinical efficacy for depression and other psychiatric disorders.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how the brain responds to repetitive magnetic brain stimulation (a non-invasive technique called rTMS) by recording electrical activity directly from the brain in people with epilepsy who already have brain monitoring electrodes placed as part of their standard care. **You may be eligible if...** - You are between 18 and 65 years old - You have medication-resistant epilepsy and are already undergoing invasive brain monitoring (phase II monitoring) as part of your epilepsy evaluation - You have the intellectual capacity to understand the study and provide informed consent - You do not have other major neurological conditions **You may NOT be eligible if...** - You have a metal implant that prevents an MRI - You have an unstable medical condition or uncontrolled neurological disease - You currently have an active substance use problem - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEIntracranial electrodes

Intracranial electrodes will be used for the delivery of invasive brain stimulation.

DEVICETMS

TMS will be used for the delivery of noninvasive brain stimulation both before and after implantation electrode surgery.


Locations(1)

Stanford University

Stanford, California, United States

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NCT05996900


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