RecruitingNot ApplicableNCT06002581

Repetitive Transcranial Magnetic Stimulation(rTMS) Regulating Slow-wave to Delay the Progression of Parkinson's Disease

Clinical Study on the Efficacy and Safety of rTMS Regulating Slow-wave Sleep to Delay the Progression of Parkinson's Disease

Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Enrollment

56 participants

Start Date

Sep 3, 2023

Study Type

INTERVENTIONAL

Conditions

Parkinson's Disease

Summary

At present, no drug therapy has been proven to delay the progression of Parkinson's disease (PD). rTMS, as a non-invasive neuromodulation method, can regulate Slow-wave sleep (SWS). SWS is recognized closely related to neurodegeneration. However, there has been no clinical studies on if rTMS could delay the progression of PD by regulating SWS. The main purpose of this study is to explore the changes of SWS in non-rapid eye movement (NREM) sleep period in PD patients by using rTMS, and the relationship with potential improvements of SWS and motor symptom delay. The study aims to find a potential new treatment strategy to delay the neurodegenerative process in PD patients by modulating SWS by rTMS.

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) — a non-invasive procedure that uses magnetic pulses to stimulate specific brain areas — can slow the progression of Parkinson's disease. **You may be eligible if...** - You have been diagnosed with Parkinson's disease (confirmed according to current diagnostic criteria) - You are of Chinese Han ethnicity, between 50 and 80 years old - Your Parkinson's severity is at a mild to moderate stage (Hoehn-Yahr stages 1 to 4) - Your medication dose has been stable for at least 3 weeks before enrolling - You are right-handed **You may NOT be eligible if...** - You have a different type of Parkinsonism (not idiopathic Parkinson's disease) - You have previously had brain surgery or TMS treatment for Parkinson's - Your cognitive test score suggests significant cognitive impairment (MMSE of 24 or below) - You have a psychiatric or intellectual disability Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICErTMS real stimulation stage1

In the first stage, the early treatment group use low-frequency rTMS real stimulation,

DEVICErTMS shame stimulation stage1

In the first stage, the control group (delayed treatment group) all use sham stimulation.

DEVICErTMS real stimulation stage 2

In the second stage, both the early treatment group and the control group (delayed treatment group) will be treated with true stimulation low-frequency rTMS.

Locations(1)

Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, China

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NCT06002581

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