RecruitingNot ApplicableNCT06003036

Accelerated Transcranial Magnetic Stimulation for People With Schizophrenia Treated With Clozapine

Accelerated Neuromodulation of Prefrontal Circuitry During Clozapine Treatment

Sponsor

Deepak K. Sarpal, M.D.

Enrollment

30 participants

Start Date

Dec 1, 2023

Study Type

INTERVENTIONAL

Conditions

Schizophrenia Schizoaffective Disorder

Summary

In this study, the investigators will examine whether a type of repetitive transcranial magnetic stimulation called accelerated intermittent theta burst stimulation (iTBS) can augment neurocognition in individuals who receive treatment with clozapine. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will undergo a session of iTBS +MRI and session of sham delivery + MRI. The order for these sessions will be blinded and randomized. The investigators predict that accelerated iTBS will enhance neurocognition relative to sham delivery.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether accelerated transcranial magnetic stimulation (TMS) — a non-invasive brain stimulation technique using magnetic pulses — can reduce symptoms in people with schizophrenia or schizoaffective disorder who are being treated with clozapine but still have persistent symptoms. **You may be eligible if...** - You have been diagnosed with schizophrenia or schizoaffective disorder - You are between 18 and 50 years old - You have been taking clozapine for at least 4 months, at a stable dose of at least 150 mg/day for the past month - You have previously tried and not responded to at least 2 other antipsychotic medications - You are able to give informed consent **You may NOT be eligible if...** - You have a serious neurological or medical condition that affects the brain - You have a significant risk of suicidal or violent behavior - You have cognitive or language limitations that prevent you from giving consent - You are pregnant or within 6 weeks of giving birth or a miscarriage - You have previously had a course of TMS treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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