RecruitingNCT06008080

Post-Market Clinical Follow Up Study With Navitor Valve

VISTA Nova Study (Navitor Post-Market Clinical Follow Up Study)


Sponsor

Abbott Medical Devices

Enrollment

1,000 participants

Start Date

Sep 29, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Evaluation of the safety and performance of the Navitor TAVI System in a Global Study


Eligibility

Min Age: 18 YearsMax Age: 100 Years

Inclusion Criteria3

  • Patient is eligible per the current approved indication after Heart Team discussion and intended to undergo a Navitor TAVI procedure.
  • The patient has been informed of the nature of the study, agrees to its provisions, and has provided written informed consent as approved by the IRB (Investigational Review Board)/EC (Ethics Committee) of the respective clinical site.
  • The patient and the treating physician agree that the subject will return for all required post procedure follow up visits.

Exclusion Criteria7

  • Patient is not eligible for the Navitor TAVI System per the current Instructions for Use (IFU)
  • Life expectancy < 12 months from the time of informed consent due to non-cardiac co-morbid conditions.
  • In the judgment of the Investigator, patient presents with a medical, social, or psychological condition that could limit the ability or willingness to participate in the study, comply with study required testing and/or follow-up visits or that could impact scientific integrity of the study.
  • Known contraindication for computed tomography (CT) or sensitivity to contrast media, which cannot be adequately premedicated.
  • Inability to tolerate antiplatelet/anticoagulation therapy or nitinol alloy (nickel and titanium), which cannot be adequately premedicated.
  • Currently participating in an investigational drug or device study that may confound the results of this study
  • Anatomy that makes insertion and endovascular access to the aortic valve difficult and/or impossible

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Interventions

DEVICENavitor Transcatheter Aortic Valve, FlexNav Delivery System, Navitor Loading System

Subjects will undergo transcatheter aortic valve replacement (TAVR) with the Navitor valve, the FlexNav Delivery system and the Navitor Loading System


Locations(35)

Royal Hobart Hospital

Hobart, Australia

Clinique du Millénaire

Montpellier, France

Mutualiste Montsouris

Paris, France

CHRU Hopital de Pontchaillou

Rennes, France

Clinique Pasteur Toulouse

Toulouse, France

Herz- u. Gefäßzentrum Bad Bevensen

Bad Bevensen, Germany

Deutsches Herzzentrum der Charité

Berlin, Germany

St Johannes Hospital Dortmund

Dortmund, Germany

Kliniken der Friedrich-Alexander-Universitat

Erlangen, Germany

Klinikum der Johann Wolfgang Goethe-Universität Frankfurt

Frankfurt, Germany

UKE Hamburg

Hamburg, Germany

Universitätsklinikum Schleswig-Holstein - Campus Kiel

Kiel, Germany

Deutsches Herzzentrum München des Freistaates Bayern

München, Germany

University Hospital Rostock

Rostock, Germany

Universitätsklinikum Ulm

Ulm, Germany

Az. Osp. Spedali Civili di Brescia

Brescia, Italy

Casa di Cura Pineta Grande

Castel Volturno, Italy

Centro Cardiologico Monzino

Milan, Italy

Ospedale San Raffaele - Cardiac

Milan, Italy

Policlinico San Donato

San Donato Milanese, Italy

Onze Lieve Vrouw Gasthuis

Amsterdam, Netherlands

ULS de Lisboa Ocidental

Carnaxide, Portugal

Hospital Universitario de Badajoz

Badajoz, Spain

Hospital Clinic de Barcelona

Barcelona, Spain

Hospital de la Santa Creu I Sant Pau

Barcelona, Spain

Hospital General Juan Ramon Jimenez

Huelva, Spain

Hospital de Gran Canaria Doctor Negrín

Las Palmas, Spain

Hospital Universitario Puerta de Hierro

Majadahonda, Spain

Consorcio Hospital General Universitario de Valencia

Valencia, Spain

Sahlgrenska University Hospital - Gothenburg

Gothenburg, Sweden

KS St. Gallen / USZ

Sankt Gallen, Switzerland

Kings College Hospital

London, United Kingdom

James Cook University Hospital

Middlesbrough, United Kingdom

Royal Stoke University Hospital

Stoke-on-Trent, United Kingdom

New Cross Hospital

Wolverhampton, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT06008080


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