BioFLO for Respiratory Recovery in SCI
Genetic Biomarkers of Intermittent Hypoxia-Induced Respiratory Motor Plasticity in Chronic SCI
University of Florida
62 participants
Dec 21, 2023
INTERVENTIONAL
Conditions
Summary
Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (\~15) of breathing low oxygen air to stimulate spinal neuroplasticity. Animal and human studies show that AIH improves motor function after spinal cord injury, particularly with slightly increased carbon dioxide (hypercapnic AIH; AIHH) and task-specific training. Using a double blind cross-over design, the study will test whether AIHH improves breathing more than AIH and whether specific genetic variations are related to individuals' intervention responses.
Eligibility
Plain Language Summary
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Interventions
AIH (acute intermittent hypoxia) consists of short episodes of low oxygen (9% O2).
AIHH consists of short episodes of low oxygen (9% O2) and elevated carbon dioxide (4% CO2).
A single session of sham AIH with episodes of normal room air (21% O2).
Locations(1)
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NCT06011876