RecruitingNot ApplicableNCT06013579

Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV

Examining the Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV (HEALTH-Cog)

Sponsor

University of Alabama at Birmingham

Enrollment

110 participants

Start Date

Aug 1, 2023

Study Type

INTERVENTIONAL

Conditions

Cognitive Impairment HIV Infections

Summary

People aging with HIV are at higher risk for Alzheimer's disease and related dementias, and although physical activity is a promising target to mitigate such risk, this population engages in low levels of physical activity. Few studies have tested cognitive effects of exercise interventions or examined mechanisms of adherence to long-term exercise among diverse samples of midlife and older people with HIV. The current study will leverage an existing R01 to address these gaps and provide implications for development of personalized approaches for the treatment and prevention of cognitive impairment and dementia in older people with HIV.

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a high-intensity supervised exercise program can reduce fatigue and cognitive decline (brain fog) in older adults living with HIV who are not very active. Participants commit to 3 exercise sessions per week for 4 months. **You may be eligible if...** - You have confirmed HIV - You have been on a stable HIV treatment regimen (ART) for at least 12 months and your viral load is undetectable - You lead a sedentary lifestyle (not regularly exercising) - You experience fatigue - You are able to participate in supervised exercise - You have a phone or email to receive messages - You weigh under 450 pounds **You may NOT be eligible if...** - You have severe anemia - You have a diagnosis of mitochondrial disease - You have active substance use problems that could interfere with attendance - You have uncontrolled high blood pressure or other serious medical conditions that make vigorous exercise unsafe - You started hormone therapy less than 3 months ago Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALPhase 1 Gym Exercise HIIT

Following a 5-minute warm-up at 50% VO2peak, high and moderate-intensity exercise bouts alternate, progressing to five bouts of 4-minute high-intensity exercise (90% VO2peak), alternating with four 3-minute bouts of moderate-intensity exercise (50% VO2peak) by week 8, followed by a 5 minute cool-down. The total exercise time is 42 minutes.

BEHAVIORALPhase 1 Gym Exercise CME

Following a 4 minute warm-up at 50% VO2peak, the participant walks for up to 42 continuous minutes at 60% VO2peak172, followed by a 4 minute cool-down. The total exercise time is 50 minutes.

BEHAVIORALPhase 2 Home Exercise Coaching Text Messages

The coaching intervention will consist of daily text messages tailored to the individual participant's self-reported symptom experiences and barriers to exercise on that specific day. One daily message with a survey will be sent, and responses to survey items will determine the subsequent once daily motivational message.Tailored messages address a range of possible barriers to adherence based on past research, and will provide advice and guidance. Text messages will be varied each week so that even if participants continue to report the same barriers they receive different text messages.

BEHAVIORALPhase 2 Home Exercise Control Text Messages

The control group will receive general daily texts from the study team (i.e., "Hope you are doing well!"), and reminding them of their next study appointments. These text messages are primarily social/generic in content and serve to maintain involvement and enhance retention of the control group.