Purinergic Signaling and the Postmenopausal Heart
PGC-1, Purines and the Postmenopausal Heart
Beth Israel Deaconess Medical Center
100 participants
Jul 1, 2019
OBSERVATIONAL
Conditions
Summary
There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic response to stress. Loss of estrogen functionality in post menopausal women may account for the increased risk of diastolic heart failure. The investigators will explore said pathways using cardiac tissue obtained from patients undergoing cardiac surgery.
Eligibility
Inclusion Criteria1
- Patients undergoing cardiac surgery under cardiopulmonary bypass.
Exclusion Criteria8
- Refusal to participate
- Emergency surgery
- Pre-existing heart block
- Preexisting atrial fibrillation
- Redo surgery
- Estrogen or hormone replacement therapy
- History of chronic heart failure
- History of major kidney disease
Interventions
Differences between men and women will be observed
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06015776