Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial

This placebo-controlled trial tests whether urolithin A (a natural supplement that supports cellular energy and mitochondrial health) taken before prostate removal surgery can affect prostate cancer biology in men with confirmed prostate adenocarcinoma. **You may be eligible if...** - You are a male 18 or older with biopsy-confirmed prostate adenocarcinoma - You are scheduled for radical prostatectomy (surgical removal of the prostate) in the next 3–6 weeks - You have adequate liver function - HIV-positive patients on effective treatment with undetectable viral load are eligible **You may NOT be eligible if...** - You have had prior primary treatment or hormonal therapy for prostate cancer - You already take urolithin A (Mitopure) or pomegranate supplements - You have active alcohol or substance dependency - You have a known allergy to urolithin A - You have uncontrolled medical illness or psychiatric conditions affecting compliance Talk to your doctor to see if this trial is right for you.