RecruitingPhase 1NCT06044857

PSMA PET Response Guided SabR in High Risk Pca

Phase IB Study of Personalized Ultrahypofractionated Stereotactic Ablative Radiotherapy of High Risk PROstate Cancer Guided by PET PSMA (68Ga PMSA-11; Ilucix) Response (PULSAR ProPhet)


Sponsor

University of Texas Southwestern Medical Center

Enrollment

20 participants

Start Date

Mar 7, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Sequential cohort evaluation of ideal timing of imaging and treatment spacing to discern maximal PSMA (Prostate specific membrane antigen) PET (Positron Emission Tomography) response (PSMA-11 68Ga, Illucix) for adaptation of dominant intra-prostatic lesion tumor boost dose


Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study uses a specialized type of PET scan (a PSMA PET scan) to guide targeted radiation treatment called SABR for men with high-risk prostate cancer. The idea is to use detailed imaging to direct radiation precisely where it is needed, potentially improving outcomes while reducing side effects. **You may be eligible if...** - You are a man diagnosed with high-risk prostate cancer - You are scheduled for or being considered for radiation therapy - You are able to undergo a PSMA PET scan **You may NOT be eligible if...** - Your cancer has spread widely to multiple distant sites - You have had prior radiation to the same area that would exceed safe limits - You have serious health conditions preventing radiation therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG68-Ga PSMA11

Will be injected/assessed in line with its FDA label.


Locations(2)

University of Texas Southwestern Medical Center

Dallas, Texas, United States

UT Southwestern Medical Center

Dallas, Texas, United States

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NCT06044857


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