RecruitingNot ApplicableNCT06032663

Use of PET-MR in Head and Neck Cancer Patients - Diagnostic and Therapeutic Applications

Sponsor

Sheffield Teaching Hospitals NHS Foundation Trust

Enrollment

10 participants

Start Date

Jan 2, 2024

Study Type

INTERVENTIONAL

Conditions

Head and Neck Cancer

Summary

The primary research question to be answered in this project is "Are patients with locally-advanced head and neck cancer able to tolerate a PET-MRI scan when they are immobilised in a radiotherapy treatment shell?" This will be assessed by measuring the proportion of patients that complete the full scanning protocol and by obtaining participant feedback on their experience of completing the scan. The secondary question is "Can a PET-MRI scan fused with a planning CT scan improve the accuracy in radiotherapy planning of patients with head and neck cancer? Accuracy will be assessed by: 1. Comparing the radiotherapy target volumes and radiotherapy plans with and without the use of a PET-MRI scan. 2. Comparing inter- and intra-observer variability in treatment contours with and without the use of a PET-MRI scan within and between oncologists and implications of that.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating whether combining PET-MR scanning (a single scan combining two types of imaging) provides better guidance for diagnosing and planning radiation treatment for head and neck cancer compared to standard imaging approaches. **You may be eligible if...** - You are 18 or older - You have a newly confirmed diagnosis of head and neck cancer (biopsy-proven) - Your treatment plan includes radiation therapy (with or without chemotherapy) - You are able to give informed written consent and read English **You may NOT be eligible if...** - You have claustrophobia or a contraindication to MRI (e.g., pacemaker or metal implants) - You are allergic to MRI contrast dye or the PET scan tracer - You are pregnant or breastfeeding - Your kidney function is significantly impaired - Your cancer is being treated with palliative (not curative) intent - Your body size prevents fitting in the MRI scanner Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTPET-MRI

Patients that participate in the current study will have an extra PET-MRI scan, which will expose them to a small amount (4 - 6 mSv) of extra radiation.