Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients
Huashan Hospital
31,440 participants
Sep 1, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients. The main questions it aims to answer are: * the proportion of MTB infection among school contacts of ATB patients * risk factors related to tuberculosis (TB) infection * health economic evaluation of screening strategy
Eligibility
Inclusion Criteria4
- years old or above;
- Students in junior middle school, high school and university;
- Close contact of school active tuberculosis case (e.g. in the same classroom, in the same dormitory);
- Himself/herself (together with his/her guardian for age under 18 years old) willing to participate in trial and sign informed consent.
Exclusion Criteria2
- Current clinical or sputum culture confirmed active tuberculosis
- Have completed a full course of treatment for ATB or LTBI
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Interventions
Participants will be tested by QuantiFERON-TB Gold (QFT) test to see if they have ever infected by MTB. Those with positive results will proceed to sputum Xpert MTB/RIF, physical examination and chest CT scan, as well as sputum culture if necessary to distinguish latent TB infection (LTBI) from ATB. X-ray scan is conditional on age above 15 years with a positive QuantiFERON-TB Gold (QFT) test result.
Locations(44)
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NCT06033807