RecruitingNCT06036563

Prospective Screening and Differentiating Common Cancers Using Peripheral Blood Cell-Free DNA Sequencing

A Multicenter Prospective Diagnostic Test: Screening and Differentiating Common Cancers (Cancers of Lung, Stomach, Colorectum, Esophagus, Liver, Breast and Pancreas) Based on Peripheral Blood Cell-Free DNA Sequencing

Sponsor

Air Force Military Medical University, China

Enrollment

3,200 participants

Start Date

Sep 1, 2023

Study Type

OBSERVATIONAL

Conditions

Liver Cancer Gastric Cancer Cancer Diagnosis LungCancer

Summary

The goal of this observational study is to screen and differentiate common cancers in participants with or without suspicious lesions. The main question the investigators aim to answer is: Can the developed model, using peripheral blood cell-free DNA sequencing, work well in screening and classifying common cancers especially in the early stages? Participants will undergo the collection of 15\~20ml of blood and 1\~2 telephone follow-up calls.

Eligibility

Min Age: 20 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether analyzing DNA fragments floating in the blood (cell-free DNA) can accurately detect and distinguish between several common types of cancer — including lung, breast, stomach, colon, liver, esophageal, and pancreatic cancer — in a simple blood test. **You may be eligible if...** - You are between 20 and 80 years old - You have been newly diagnosed with one of the above cancers (confirmed by biopsy within the past 90 days), OR - You are a healthy person (no cancer) undergoing a routine health check **You may NOT be eligible if...** - You have an active autoimmune disease, tuberculosis, or HIV - You have had any cancer treatment in the past 3 years - You have had an organ or bone marrow transplant - You are pregnant or breastfeeding - You have a fever, recent severe infection, or blood-clotting condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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