RecruitingNot ApplicableNCT06038929

Effect of Vagal Nerve Stimulation on Gastric Motor Functions

REVEAL - Research Evaluating Vagal Excitation and Anatomical Linkages Gastric Emptying Ancillary Project: Effect of Vagal Nerve Stimulation on Gastric Motor Functions

Sponsor

Mayo Clinic

Enrollment

16 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Depression Epilepsy

Summary

The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to a caloric meal In patients who have previously undergone activation of left cervical VNS for the treatment of medication-resistant depression. Our hypothesis is that cervical VNS increases gastric accommodation and accelerates gastric emptying compared to a bank of healthy control data.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring how a vagus nerve stimulator (a small implanted device that sends electrical pulses to the brain) affects the way the stomach moves and functions in patients who already have this device implanted for epilepsy or depression. **You may be eligible if...** - You are 18 years old or older - You have been diagnosed with drug-resistant epilepsy or treatment-resistant depression and already have a vagus nerve stimulator (VNS) implanted - Your VNS settings have been stabilized by your care team - You are otherwise medically and neurologically stable - You are able to attend regular clinic visits **You may NOT be eligible if...** - You do not have an implanted vagus nerve stimulator - You have significant other medical or neurological conditions that would interfere with the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEVagal nerve stimulant

Vagus nerve stimulation involves using a device to stimulate the vagus nerve with electrical impulses. The implanted electrodes transmit electrical impulses travel to areas of the brain to treat conditions (intractable epilepsy, depression) and also send electrical impulses to the stomach.

Locations(2)

University of Minnesota

Minneapolis, Minnesota, United States

Mayo Clinic in Rochester

Rochester, Minnesota, United States

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NCT06038929

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