RecruitingNCT06045780

HO-1/CREB3 Modulates Golgi Stress in Patients With Sepsis

Study on the Mechanism of Endotoxic Acute Lung Injury-induced Golgi Stress Based on Regulating HO-1/CREB3

Sponsor

Tianjin Nankai Hospital

Enrollment

150 participants

Start Date

Sep 15, 2023

Study Type

OBSERVATIONAL

Conditions

Sepsis

Summary

This study was an ambispective observational cohort study that included sepsis patients hospitalized in the Intensive care unit (ICU) of the Nankai Hospital. All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Inclusion Criteria4

Males or females over the age of 18;
Sepsis was diagnosed within 48h which meets SPESIS 3 criteria;
Capable of understanding the purpose and risk of the study;
Patients or proxy must give written informed consent before any assessment is performed.

Exclusion Criteria6

Pregnancy, lactation or perinatal period;
Breast carcinoma;
HIV seropositive or Syphilis seropositive;
Any clinical-relevant condition that might affect study participation and/or study results;
Participation in any other intervention trial;
Unwillingness or inability to following the study protocol in the investigators opinion.