RecruitingNCT06193980

ICU Combined Assessment of Cardio-Respiratory Exercise

Exercise Testing in ICU Survivors to Evaluate ICU-acquired Weakness

Sponsor

University of Manitoba

Enrollment

50 participants

Start Date

Dec 15, 2023

Study Type

OBSERVATIONAL

Conditions

ICU acquired weakness microcirculation Sepsis Critical Illness Shock

Summary

This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness/dysfunction or ICU-Acquired Weakness (ICU-AW) and exercise limitations.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

Patients who have received mechanical ventilation for at least 7 days in the intensive care unit (ICU) and have subsequently been discharged from hospital.

Exclusion Criteria9

Unable to provide consent
Trajectory of health expected to be significantly limited in the upcoming 12 months
those who self-report that they cannot climb at least one flight of stairs due to limited exercise capacity
have significant orthopedic or musculoskeletal impairment affecting mobility
have a medical history of neuromuscular disease
ongoing respiratory limitations (i.e., supplemental oxygen)
significant heart disease (i.e. ejection fraction less than 30%, unstable ischemic heart disease, severe valvular heart disease)
a body mass index (BMI) of ≥ 40 kg/m2 (impacting NIRS signal due to adipose tissue thickness)
if participant's primary residence is a significant distance from Winnipeg