Estimation of the Dietary Requirement for Vitamin D in Ethnic Groups
Estimation of the Dietary Requirement for Vitamin D in Ethnic Groups: a Double-blind, Randomised, Dose-response Trial
University of Surrey
114 participants
Nov 1, 2023
INTERVENTIONAL
Conditions
Summary
The aim of this study is to perform a double-blind, randomised, dose-response trial of vitamin D3 supplementation in United Kingdom (UK)-dwelling adults of white European, South Asian, and black African/Caribbean ethnicity to investigate the distribution of dietary intakes needed to maintain adequate vitamin D status in winter, as indicated by serum 25(OH)D concentrations at ranges of \>25 to 50 nmol/L. In addition, this study will investigate the effect of vitamin D3 supplementation on immune health, muscular strength, and overall health.
Eligibility
Inclusion Criteria5
- British white European, black African/Caribbean, or South Asian (self-reported)
- Living in England for >2 months
- Aged >18 years
- No significant health issues
- English or Urdu speaker
Exclusion Criteria7
- Medical condition or history which might impact study measurements (e.g., ischaemic heart disease, type 1 and type 2 diabetes, thyroid disease, osteoporosis, haematological disease, malignancy)
- Medications known to affect vitamin D metabolism (i.e., hormone replacement therapy, anti-oestrogens treatment, antiepileptic drugs, and breast cancer treatment)
- Pregnant or planning pregnancy during the study period
- Regular use of sun beds
- Having a sun holiday one month prior to commencing study or plans for a sun holiday within the study period. A sun holiday is generally defined as a holiday in a sunny resort outside of the UK. The researchers will assess this on a case-by-case basis depending on the time of year and expected weather conditions
- Reported participation in another clinical trial occurring simultaneously
- Previous intolerance or allergic reaction to vitamin D
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Interventions
Vitamin D Supplement
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06067477