Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.
Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention (STAK - Sleep + Feed)
Ohio State University
60 participants
May 1, 2023
INTERVENTIONAL
Conditions
Summary
Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks. Ketogenic supplementation is speculated to alleviate some sleep deprivation issues via action of ketones. Ketones are small molecules that appear in the blood when following a ketogenic diet or consuming ketone supplements. The goal of this project is to find out if diet and/or ketones can improve sleep deprivation detriments over 5 days of sleep restriction (-50% from habitual sleep).
Eligibility
Inclusion Criteria5
- Healthy, 18-40 years old.
- BMI: 20-35 kg/m2
- Sleep at least 7h per night.
- Willing to participate in \~9-weeks of testing and provided food.
- Willing to adhere to all study procedures.
Exclusion Criteria11
- \<18 or \>40 years of age
- \>35 body mass index (BMI).
- Diagnosed sleeping disorders (i.e., sleep apnea, insomnia).
- Gastrointestinal disorders or food allergies that would interfere with consuming the study supplements.
- Drink alcohol in excess of 3 drinks/day or 14 drinks/week
- Have any conditions or contraindications to blood draws.
- Have been diagnosed with diabetes, liver, kidney, or other metabolic or endocrine dysfunction, or use diabetic medications other than metformin
- Currently consume a low carbohydrate or ketogenic diet or have done so in the last 3 months
- Have experienced weight loss of \>10% of your body weight within the last 6 months
- Are pregnant, lactating, or planning on becoming pregnant during the study
- Have any major psychiatric disorders (e.g., schizophrenia, bipolar disorder)
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Interventions
Participants will receive ready-to-eat Ketogenic Diet meals.
Participants will receive ready-to-eat Mediterranean Diet meals.
Participants will receive twice-daily placebo servings to be consumed once in the morning and once before sleep.
Participants will receive twice-daily ketone ester servings to be consumed once in the morning and once before sleep.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06075914