RecruitingNot ApplicableNCT06077292

Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults

Impacts of THC Potency of Cannabis Concentrates and THC Metabolism on Cognitive Impairment in Young Adults

Sponsor

University of California, San Francisco

Enrollment

110 participants

Start Date

Mar 17, 2025

Study Type

INTERVENTIONAL

Conditions

Cognitive Impairment Cannabis Use THC Marijuana Use THC Vaping

Summary

The goal of this interventional study is to determine the impact of high potency THC product use on cognitive function of young adults aged 21-25. The main question it aims to answer is: will cannabis users who switch to less potent THC products demonstrate improved cognitive function compared to baseline? Other questions this study aims to answer include: * Can researchers accurately assess THC consumption among frequent cannabis users? * Can researchers effectively incentivize cannabis users to use less potent THC products? * Do genetic variations in THC metabolism impact urinary THC excretion? * Do genetic variations in THC metabolism impact cognitive performance in cannabis users? * Are quantitative urinary THC values predictive of cognitive impairment? * How can researchers use research findings to inform harm reduction practices for people who use cannabis? Participants will submit blood and urine samples and be incentivized to use less potent THC products.

Eligibility

Min Age: 21 YearsMax Age: 25 Years

Inclusion Criteria5

Between the ages of 21-25
Resides in San Francisco
Self-report cannabis concentrate use as their primary method of cannabis use
Self-report using cannabis daily or almost daily (i.e., at least 6 out of 7 days during each of the last 4 weeks)
Self-report only purchasing cannabis from regulated retail stores in California.