RecruitingNot ApplicableNCT06080841

Curcumin Supplementation in Cervical Cancer

Evaluation of Curcumin Supplementation on p53 Levels and Apoptosis in Tumor Cells From Patients With Locally Advanced Cervical Cancer


Sponsor

National Institute of Cancerología

Enrollment

30 participants

Start Date

Apr 19, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Brief Summary. The goal of this pilot study is to learn about the effect of curcumin supplementation in locally advanced cervical cancer patients. The main questions it aims to answer are: * Does curcumin supplementation increase the levels of p53 and apoptosis in tumor cells from cervical cancer patients? * At which dose of curcumin supplementation is the broader effect observed for p53 expression and apoptosis in tumor cells from cervical cancer patients? * Are all doses safe for supplementation? Participants will be asked to take curcumin tablets throughout their cancer treatment. Researchers will compare 6 different groups, each group will receive a different dose of curcumin with or without piperin, to see the dose with the broader effect and safety of curcumin supplementation: 1. 1 g of curcumin 2. 1 g of curcumin + piperine 3. 3 g of curcumin 4. 3 g of curcumin + piperine 5. 6 g of curcumin 6. 6 g of curcumin + piperine


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether taking curcumin (the active ingredient in turmeric) as a supplement can help improve treatment outcomes for women with cervical cancer undergoing radiation and chemotherapy. **You may be eligible if...** - You are a woman over 18 years old - You have been diagnosed with cervical cancer (squamous cell, adenocarcinoma, or related types) - Your cancer is stage IB3 through IVA (locally advanced) - You are about to receive concurrent chemotherapy and radiation therapy - Your blood counts and organ function are within acceptable ranges **You may NOT be eligible if...** - You are already taking turmeric, curcumin, ginger, or related dietary supplements - You have another active cancer - You have serious uncontrolled infections or other illnesses - You have an abnormal fistula (abnormal connection) between your bladder and vagina or rectum - You are currently enrolled in another experimental drug trial Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTCurcumin

Patients will receive capsules with curcumin C3 (Sabinsa Corp, NJ, USA) containing 1g of curcumin. They will be instructed to consume orally 1 capsule with breakfast for group 1, 1 capsule with each meal for group 3, and 2 capsules with each food for group 5.

DIETARY_SUPPLEMENTCurcumin + Piperine

Patients will receive capsules with curcumin C3 (Sabinsa Corp, NJ, USA) containing 1g of curcumin additioned with 5 mg of piperine. They will be instructed to consume orally 1 capsule with breakfast for group 2, 1 capsule with each meal for group 4, and 2 capsules with each meal for group 6.


Locations(1)

Instituto Nacional de Cancerología

Mexico City, Mexico City, Mexico

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NCT06080841


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