The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED)

This study tests whether colchicine — a common anti-inflammatory medication used for gout — can help people with heart failure with preserved ejection fraction (a type of heart failure where the heart pumps normally but is too stiff). Researchers believe reducing inflammation may ease symptoms. **You may be eligible if...** - You have been diagnosed with heart failure with a preserved pumping function (ejection fraction of 45% or more) - You have had heart failure symptoms for at least 30 days and currently have symptoms (shortness of breath, fatigue) - Your echocardiogram shows structural heart changes consistent with this type of heart failure - Your BNP blood test level is elevated - Your BMI is under 40 **You may NOT be eligible if...** - You are already taking colchicine for gout or another reason - You are allergic to colchicine - You have very high blood pressure, severe liver disease, or kidney disease (low kidney function) - You have a history of cancer (except some skin cancers) - You have recently been hospitalized for heart failure, heart attack, or major cardiac surgery - You are pregnant, breastfeeding, or planning pregnancy - You have inflammatory bowel disease or chronic diarrhea Talk to your doctor to see if this trial is right for you.