RecruitingNot ApplicableNCT06083064

Protocol Based Selective Imaging Versus Routine Computed Tomography or Ultrasound in Suspected Appendicitis

Protocol Based Selective Imaging Versus Routine Computed Tomography or Ultrasound in Suspected Appendicitis (PROSECCO)


Sponsor

Helsinki University Central Hospital

Enrollment

900 participants

Start Date

Nov 15, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to compare protocol based selective imaging to routine imaging in adult patients with suspected appendicitis. The main question\[s\] it aims to answer are: * Does protocol based selective imaging using clinical scoring affect clinical outcome? * Does protocol based selective observation combined with score based selective imaging affect clinical outcome? Participants will be randomized into three groups: * Selective imaging based on Adult Appendicitis Score * Selective observation based on Appendicitis Severity Score combined with selective imaging based on Adult Appendicitis Score * Routine imaging using ultrasound and/or computed tomography Researchers will compare selective imaging groups separately with routine imaging to see if number of negative appendectomies or number of complicated appendicitis is not significantly increased.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • \- Suspicion of appendicitis

Exclusion Criteria6

  • Time from symptom onset over 72 hours
  • Age \<18 years
  • Pregnancy, ruled out by serum or urine HCG measurement in 18- to 49-year-old women
  • CT-scan or ultrasound already done within the last 3 days (72 hours)
  • Clinical suspicion of other disease or other reason to perform imaging study
  • Recruited earlier to the same trial

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Interventions

DIAGNOSTIC_TESTAbdominal imaging

Abdominal ultrasound and/or abdominal CT

OTHERScore based selective abdominal imaging

Abdominal imaging is done selectively based on Adult Appendicitis Score

OTHERScore based selective observation combined with selective abdominal imaging

Observation based on Appendicitis Severity Score combined Adult Appendicitis Score based selective abdominal imaging


Locations(3)

HUS, Jorvi Hospital

Espoo, Finland

HUS, Meilahti Hospital

Helsinki, Finland

HUS, Hyvinkää Hospital

Hyvinkää, Finland

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NCT06083064


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