Appendicitis Clinical Trials

45 recruitingLast updated: July 25, 2026

There are 45 actively recruiting appendicitis clinical trials across 25 countries. Studies span Not Applicable, Phase 3, Phase 4, Phase 1. Top locations include Washington D.C., District of Columbia, United States, Angers, Pays de la Loire Region, France, Ankara, Turkey (Türkiye). Updated daily from ClinicalTrials.gov.


Appendicitis Trials at a Glance

45 actively recruiting trials for appendicitis are listed on ClinicalTrialsFinder across 6 cities in 25 countries. The largest study group is Not Applicable with 20 trials, with the heaviest enrollment activity in Washington D.C., Angers, and Ankara. Lead sponsors running appendicitis studies include Centre Hospitalier Universitaire de Nice, Dr Brodie Elliott, and Ankara City Hospital Bilkent.

Browse appendicitis trials by phase

Treatments under study

About Appendicitis Clinical Trials

Looking for clinical trials for Appendicitis? There are currently 29 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Appendicitis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Appendicitis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 45 trials

Recruiting
Not Applicable

The Impact of a Diagnostic Strategy for Acute Appendicitis in Children With Acute Abdominal Pain in Primary Care

Appendicitis AcuteAcute Abdomen in Children
University Medical Center Groningen566 enrolled1 locationNCT06762275
Recruiting
Not Applicable

Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy

Respiratory ComplicationsAppendicitis AcutePostoperative Sore Throat, Cough, Hoarseness+1 more
Ankara Etlik City Hospital60 enrolled1 locationNCT07678086
Recruiting
Not Applicable

Feasibility and Safety of a Pediatric ERAS Protocol for Laparoscopic Appendectomy

Acute appendicitisERASPediatric Surgery+1 more
Ahmet Burak Doğan, MD100 enrolled1 locationNCT07643285
Recruiting
Not Applicable

Oral Lactulose for Gastrointestinal Recovery After Complex Appendectomy

Ileus PostoperativeGastrointestinal FunctionComplicated Appendicitis
Nanchong Central Hospital150 enrolled1 locationNCT07589465
Recruiting
Not Applicable

Effects of Cartoons and Mobile Games on Preoperative Anxiety and Fear in Children With Appendicitis: An RCT

Preoperative AnxietyFearChildren+1 more
Ankara City Hospital Bilkent69 enrolled1 locationNCT07640230
Recruiting
Not Applicable

Early Detection of Infection Using the Fitbit in Pediatric Surgical Patients

AppendectomyAppendicitisAppendicitis Acute
Ann & Robert H Lurie Children's Hospital of Chicago500 enrolled4 locationsNCT06395636
Recruiting

Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study

pyelonephritisDiverticulitisAppendicitis Acute+2 more
True Bearing Diagnostics, Inc.1,000 enrolled1 locationNCT07579312
Recruiting

Retrospective Acute Care Appendectomy Study

Acute appendicitis
Intuitive Surgical1,000 enrolled3 locationsNCT06624215
Recruiting
Not Applicable

Out-patiente Management for Gangrenous Acute Appendicitis: The PENDI-CSI II Randomized Clinical Trial.

Appendicitis AcuteGangrenous Appendicitis
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla122 enrolled1 locationNCT07521969
Recruiting

Re-assessment of Appendicitis Evaluation During Laparoscopic Appendectomy, Peritoneal Irrigation During Laparoscopic Appendectomy Does the Grade of Contamination Matter?

AppendectomyAppendicitis
Niguarda Hospital1,067 enrolled1 locationNCT05075252
Recruiting
Not Applicable

Same Day Ambulatory Appendectomy (SAMBA)

Appendicitis
Centre Hospitalier Universitaire de Nice1,400 enrolled33 locationsNCT05691348
Recruiting

Comparison of Diagnostic Methods in Patients Operated for Suspected Appendicitis

Acute appendicitis
Sanliurfa Education and Research Hospital200 enrolled1 locationNCT07496723
Recruiting
Phase 4

Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics

Laparoscopic AppendectomyComplicated AppendicitisPeriappendicular Abscess
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau772 enrolled7 locationsNCT05761080
Recruiting

Clinical Study of PEG Bowel Preparation in Appendectomy Patients

AppendicitisAppendicitis Acute
Huaping Xie10 enrolled1 locationNCT07478029
Recruiting
Phase 1

Precision Antibiotic Dosing for Appendectomy

Appendicitis (Diagnosis)
University of Michigan46 enrolled1 locationNCT06860802
Recruiting
Phase 4

APPI-Cost Trial for Perforated Appendicitis

Perforated Appendicitis
The University of Texas Health Science Center, Houston346 enrolled1 locationNCT06705842
Recruiting
Not Applicable

Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon

Appendicitis
Yale University180 enrolled1 locationNCT04168866
Recruiting
Not Applicable

Benefit of Hypnosis on Smartphone for Acute Post-operative Pain (HYPNO-APP)

Appendicitis With Peritonitis
Centre Hospitalier Universitaire de Nice20 enrolled1 locationNCT05854914
Recruiting
Not Applicable

Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure

Appendicitis
Sohag University80 enrolled1 locationNCT07115303
Recruiting
Not Applicable

PAINED: Project Addressing INequities in the Emergency Department

AppendicitisPainFractures, Bone+1 more
Children's National Research Institute22,032 enrolled1 locationNCT05488080